Dr Pranav Vasanthi BathrinarayananPhD
School of Chemical Engineering
University of Birmingham
In-vitro modelling, Organ-on-a-chip, Human airways, Tissue engineering, Biomaterials, Hydrogels
Recent advances in biomaterials, tissue engineering and micro-fluidics have given birth to a novel field of in-vitro modelling called organ-on-a-chip technology which aim to recapitulate the native in-vivo micro-environment of an organ/tissue, thus forming a critical bridge between traditional in-vitro submerged culture models and animal models. Such bio-mimetic chips would be a great asset in bolstering accelerated, cost-effective and physiologically relevant high-throughput screening in the drug-development process. As a Research fellow, my current project is focused on employing thermophorectically manipulated hydrogels of varying stiffness gradients in order to investigate the mechanobiological aspects of pulmonary fibrosis.
I predominantly work at the interface of biology and engineering. I perceive myself as a basic cell biologist and hence would love to collaborate with people who can compliment the engineering aspects relevant to my project such as: biomaterials (hydrogels), 3D printing, advanced microscopy such as single cell imaging. I am also seeking expertise in advanced molecular biology skills such as single-cell RNA seq, CRISPR/cas9 gene editing etc.