Organ-on-a-Chip Network & Emulate Proof of Concept Award

The UK Organ-on-a-Chip Network and Emulate, Inc. offered these awards to Network members via the Queen Mary+Emulate Organs-on-Chips Centre.  For further information, please visit the Centre webpage:  Proof of Concept Award

 Information on the projects receiving this award is provided below. 

Award Round 3

Chip model of placental and fetal membranes to characterise damage caused by particles of air pollution

Principal investigator: Tina Chowdhury, Queen Mary University of London
Co-investigators: Stefaan Verbruggen, University of Sheffield
Jonathan Grigg, Queen Mary University of London
Anna David, University College London
Award round: 3

Defining the interaction of nanomedicines with the small intestine

Principal investigator: Driton Vllasaliu, Kings College London
Co-investigators: Julia Mantaj, Anglia Ruskin University
Award round: 3

Developing liver-on a chip models with primary human liver endothelial cells to test novel liver directed immunotherapies

Principal investigator: Shishir Shetty, University of Birmingham
Co-investigators: Peter Hewett, University of Birmingham
Award round: 3

Impact of undernutrition-exposed monocytes on gut barrier function

Principal investigator: Claire Bourke, Queen Mary University of London
Co-investigators: Tafhima Haider, Queen Mary University of London
Award round: 3

Investigating the pro-metastatic cross-talk between amoeboid cancer cells and tumour microenvironment in a cancer-on-chip model

Principal investigator: Victoria Sanz-Moreno, Queen Mary University of London
Co-investigators: Remi Samain, Queen Mary University of London
Award round: 3

Towards a biomicrofluidic model of the enterocyte-lymphatic interface to study the intestinal transport of lipid-soluble drugs

Principal investigator: Nazila Kamaly, Imperial College London
Co-investigators: Oscar Ces, Imperial College London
Jake Samuel, Imperial College London
Award round: 3

Award Round 2

Development of a human placental artery-on-a-chip to study placental vascular function in reproductive toxicology and pregnancy diseases

Principal investigator: Teresa Tropea, University of Manchester
Co-investigators: Paul Brownhill, University of Manchester
Virginia Pensabene, University of Leeds
Award round: 2

Generation and validation of a urine-derived, personalised kidney-on-chip model for kidney disease and nephrotoxicity

Principal investigator: John Sayer, Newcastle University
Co-investigators: Elisa Molinari, Newcastle University
Award round: 2

Investigating the role of tumour associated myeloid cells on malignant cell invasion in a metastatic high-grade serous ovarian cancer-on-chip model

Principal investigator: Fran Balkwill, Queen Mary University of London
Co-investigators: Mina Mincheva, Queen Mary University of London
Award round: 2

Production and validation of a bovine lung-on-a-chip to study bovine respiratory diseases

Principal investigator: Mark Chambers, University of Surrey
Co-investigators: Diane Lee, University of Surrey
Geoff Smith, North Carolina State University
Ronald Baynes, North Carolina State University
Award round: 2

Award Round 1

Advancing Human Synovial Joint Chips

Principal investigator: Karina Wright, Keele University
Co-investigators: Sally Roberts, Keele University
Charlotte Hulme, Keele University
Award round: 1

Interrogating the role of hydrolases on colonic barrier dysfunction

Principal investigator: Rachael Barry, Imperial College London
Award round: 1

Investigating the diagnostic and drug-screening potential of endothelial-tomesenchymal transition during liver fibrosis

Principal investigator: Neil Dufton, Queen Mary University of London
Co-investigators: James Whiteford, Queen Mary University of London
Award round: 1

Modelling anti-fungal immunity in the human intestine

Principal investigator: Neil McCarthy, Queen Mary University of London
Co-investigators: Carol Munro, University of Aberdeen
Daniel Pennington, Queen Mary University of London
Award round: 1