Dr Neil Dufton
Lecturer in Inflammatory Sciences
Queen Mary University of London
Endothelial-to-mesenchymal transition, fibrosis, inflammation
The adaptability and plasticity of blood vessels, and particularly the cells that line them, termed endothelial cells (EC) are fundamental to both vascular and tissue development, homeostasis and disease pathogenesis. I focus on visualising pathways that result in disease-associated endothelial phenotypes, such as endothelial-to-mesenchymal transition (EndMT), in models of inflammation and fibrosis and how they impact the surrounding tissue.