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Organ-on-a-Chip Technologies Network

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Pump-prime Projects

Our sabbatical funding helps to deliver Organ-on-a-Chip Technologies Network (OOACT) aims which include: stimulating new collaborations between network members, and integrating research activity across traditional research disciplines.

Award Round 1

In our first award round announced in October 2018, we funded five sabbatical pump-prime projects with a total spend of £85,227.  For more news on this funding round, please read: "Funding stimulates new collaborations in organ-on-a-chip technologies"

Award Round 2

In our second award round announced in April 2019, we funded three sabbatical pump-prime projects with a total spend of £47,033. 

Award Round 3

In our final award round announced in September 2020, we funded ten pump-prime projects with a total spend of £209,202 

Information on the OOACT Network funded projects from all three rounds is shown below:

Development of a multi-scale microfluidic tissue platform for modelling complex vascular and immune functions

Principal investigator: John Connelly, Queen Mary University of London
Co-investigators: Frederik Claeyssens, University of Sheffield
Daniel Aeschlimann, Cardiff University
Zulfiqur Ali, Teeside University
Pelin Candarlioglu, GlaxoSmithKline
Adrian Biddle, Queen Mary University of London
Lorenzo Veschini, Kings College London
Researchers: Liisa Blowes, Queen Mary University of London
Award round: 3
Dates: Start: 01-05-2021  /  End: 31-10-2021
Contract amount: £8,000

Streptococcus pneumoniae infection on a human lung-on-chip model

Principal investigator: Caroline Weight, University College London
Co-investigators: Robert Heyderman, University College London
Hywel Morgan, University of Southampton
Emily Swindle, University of Southampton
Researchers: Caroline Weight, University College London
Nikita Karra, University of Southampton
Award round: 3
Dates: Start: 01-05-2021  /  End: 31-10-2021
Contract amount: £21,638

Design of a microfluidics device for studies of breast cancer metastasis and tissue-resident macrophages induced niche priming

Principal investigator: Justin Stebbing, Imperial College London
Co-investigators: Volker Lauschke, Karolinska Institute, Sweden
Researchers: Nina Moderau, Imperial College London
Award round: 3
Dates: Start: 01-04-2021  /  End: 31-07-2021
Contract amount: £24,000

Feeling the force: Enhancing OOAC capability for biomechanical assessment and application

Principal investigator: Pierre Bagnaninchi, University of Edinburgh
Co-investigators: Jerome Charmet, University of Warwick
Alicia El Haj, University of Birmingham
Researchers: Andras Kufcsak, University of Edinburgh
Luo Luo, University of Birmingham
Award round: 3
Dates: Start: 01-03-2021  /  End: 31-07-2021
Contract amount: £23,471

Emulate-Bladder: A new dynamic in vitro human bladder model

Principal investigator: Mark Chambers, University of Surrey
Co-investigators: Hardev Pandha, University of Surrey
Clare Thompson, Queen Mary University of London
Martin Knight, Queen Mary University of London
Researchers: Guy Simpson, University of Surrey
Award round: 3
Dates: Start: 26-04-2021  /  End: 25-07-2021
Contract amount: £23,952

3D Printed Vascularised Polymer Scaffolds: Towards a Womb-on-a-Chip Model to Study Human Embryo Implantation

Principal investigator: Ahmed Eissa, University of Warwick
Co-investigators: Jan Brosens, University of Warwick
Researchers: Ahmed Eissa, University of Warwick
Emma Salisbury, University of Warwick
Award round: 3
Dates: Start: 25-01-2021  /  End: 24-07-2021
Contract amount: £23,730

TEER imaging platform for OOAC: spatially resolved TEER measurement at the cellular level

Principal investigator: Jerome Charmet, University of Warwick
Co-investigators: Jiabin Jia, University of Edinburgh
Pierre Bagnaninchi, University of Edinburgh
Paul Holloway, University of Oxford
Researchers: Rui Rodrigues, University of Warwick
Graham Anderson, University of Edinburgh
Award round: 3
Dates: Start: 01-03-2021  /  End: 30-06-2021
Contract amount: £23,822

Adenomyosis-on-a-chip: a microfluidic 3D model of the endometrial-myometrial junction (EMJ)

Principal investigator: Mairi Sandison, University of Strathclyde
Co-investigators: Michele Zagnoni, University of Strathclyde
Dharani Hapangama, University of Liverpool
Researchers: Caroline Busch, University of Glasgow
Award round: 3
Dates: Start: 06-04-2021  /  End: 20-06-2021
Contract amount: £22,610

Feasibility study to assess the use of organ-on-a-chip technology for optimization of radiotherapy cancer treatment

Principal investigator: Giuseppe Schettino, University of Surrey
Co-investigators: Eirini Velliou, University of Surrey
Researcher co-investigators: Miriam Barry, National Physical Laboratory
Researchers: Priyanka Gupta, University of Surrey
Chiara De Lucia, University of Surrey / NPL
Award round: 3
Dates: Start: 06-04-2021  /  End: 20-06-2021
Contract amount: £21,190

Engineering vascularised pancreatic islets on a chip to report on the functional connectivity of insulin-producing beta cells

Principal investigator: Victoria Salem, Imperial College London
Co-investigators: Joseph Sherwood, Imperial College London
Researchers: Kinga Suba, Imperial College London
Award round: 3
Dates: Start: 15-03-2021  /  End: 14-06-2021
Contract amount: £16,789

Incorporating the circadian clock into Organ-on-a-Chip (OOAC) devices

Principal investigator: David Lee, Queen Mary University of London
Co-investigators: John O'Neill, MRC Laboratory of Molecular Biology, Cambridge
Researcher co-investigators: Tom Nightingale, William Harvey Research Institute, London
Researchers: Hannah Heywood, Queen Mary University of London
Award round: 2
Dates: Start: 01-04-2020  /  End: 25-10-2020
Contract amount: £19,669

Isogenic human neurovascular unit on chip: towards a disease on chip model of stroke

Principal investigator: Alistair Buchan, University of Oxford
Co-investigators: Chris Hughes, University of California Irvine
Abraham Lee, University of California Irvine
Researcher co-investigators: Paul Holloway, University of Oxford
Award round: 2
Dates: Start: 01-10-2019  /  End: 01-04-2020
Contract amount: £18,404

Organoid modelling of the tumour immune microenvironment

Principal investigator: Daniela Loessner, Queen Mary University of London
Co-investigators: Aideen Ryan, National University of Ireland, Galway
Nick Leslie, Heriot-Watt University
Researcher co-investigators: Niamh Leonard, National University of Ireland, Galway
Award round: 2
Dates: Start: 01-11-2019  /  End: 31-03-2020
Contract amount: £8,960

Microfluidic model of human pulmonary artery: vascular cell positioning under flow

Principal investigator: Beata Wojciak-Stothard, Imperial College London
Co-investigators: Virginia Pensabene, University of Leeds
Researchers: Alexander Ainscough, Imperial College London
Vanessa Mancini, University of Leeds
Award round: 1
Dates: Start: 01-08-2019  /  End: 30-11-2019
Contract amount: £14,400

Next-Generation Material for high-volume production of Sustainable, Biocompatible Organ-On-Chip devices

Principal investigator: Maïwenn Kersaudy-Kerhoas, Heriot-Watt University
Co-investigators: Virginia Pensabene, University of Leeds
Eugenio Martinelli, University of Rome Tor Vergata
Holger Becker, Microfluidic ChipShop GmbH
Maciej Skolimowski, Micronit Microtechnologies BV
Researcher co-investigators: Sandro Meucci, Micronit Microtechnologies BV
Francesco Colucci, University of Leeds
Researchers: Alfredo Ongaro, Heriot-Watt University
Award round: 1
Dates: Start: 01-04-2019  /  End: 31-10-2019
Contract amount: £10,627

Development of a microvascularised cerebral organoid-on-a-chip

Principal investigator: Julien Gautrot, Queen Mary University of London
Co-investigators: Madeline Lancaster, MRC Laboratory for Molecular Biology
Researchers: Stefania Di Cio, Queen Mary University of London
Award round: 1
Dates: Start: 04-02-2019  /  End: 03-08-2019
Contract amount: £22,886

Development of an immune-responsive 3D skin model

Principal investigator: John Connelly, Queen Mary University of London
Co-investigators: John Greenman, University of Hull
Matthew Hardman, University of Hull
Researchers: Ana Laly Aguedo, Queen Mary University of London
Award round: 1
Dates: Start: 04-01-2019  /  End: 31-07-2019
Contract amount: £17,008

Transcriptional development of human primary osteocytes in a 3D bone organ

Principal investigator: Phillipa Hulley, University of Oxford
Co-investigators: Liam Grover, University of Birmingham
Adam Cribbs, University of Oxford
Researcher co-investigators: Anastasios Chanalaris, University of Oxford
Award round: 1
Dates: Start: 14-01-2019  /  End: 30-06-2019
Contract amount: £20,306