Dr Adrian Biddle
Queen Mary University of London
cancer, stem cells, human development, human models, heterogeneity, cell biology
My research uses human cancer models, with a focus on cancer stem cells, phenotypic heterogeneity, and developmental processes. In my group, we have progressed from simple 2D human cell line models to 3D models and models employing fresh human tumour specimens. These have enabled greater in vivo relevance, but there is still a long way to go towards accurately mimicking the in vivo tumour environment, especially the metastatic cascade. Ultimately, we want to be able to assay the role of cancer stem cells at every step of tumour development and metastasis within an in vitro tumour-on-a-chip setting.