Prof Giulio Cossu
Constance Thornley Professor of Regenerative Medicine
Division of Cell matrix Biology and Regenerative Medicine
University of Manchester
Cell and gene therapy, Muscular dystrophies, Muscle differentiation, Pericytes
I would like to recreate, on a chip, a miniaturised human muscle, either healthy or dystrophic, by combining myogenic, vascular cells and motoneurons, with appropriate ECM components or biomaterials. This would allow a medium-throughput study of the effect of cell or gene or drug therapy on the production of the protein mutated in the specific form of muscular dystrophy.