Professor Lou Metherell

Lou Metherell

Professor of Endocrine Genetics

Centre for Endocrinology, William Harvey Research Institute
Queen Mary University of London
LocationUnited Kingdom

Research Interests

Adrenal, Endocrine, Cardiovascular, Genetics

The adrenal gland controls a plethora of crucial physiological functions, and dysfunction is associated with severe morbidity. Patients with adrenal Insufficiency need life-long management with exogenous steroids: this can be challenging as no drug suitably mimics the diurnal pattern of cortisol, and measuring the quality of replacement therapy is problematic. Fine-tuning of replacement therapy leaves only a narrow margin for improvement. We seek to improve current treatment options for patients with adrenal insufficiency in addition to working towards the ultimate goal of a cure by transplantation of patient-derived, gene-corrected adrenal organoids.