Dr Sharon Dewitt
Matrix Biology and Tissue Repair, School of Dentistry, College of Biological and Life Sciences
029 2251 0665
Cartilage, Osteoarthritis, Matrix, Inflammation, Neutrophil, Biomarker
Osteoarthritis remains a major challenge, with no disease modifying drugs available. Development of an artificial synovial joint would facilitate identification of early disease markers and also facilitate rapid drug screening. We have developed a 3D cartilage model from human chondrocyte progenitor cells, which has similar biochemical, histological and mechanical properties to native human articular cartilage. We hope to integrate our cartilage model with other joint-relevant material (bone, synovium, etc) to create an in vitro system that can replicate joint tissue responses.