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Dr Sharon Dewitt

Lecturer

Department  Matrix Biology and Tissue Repair, School of Dentistry, College of Biological and Life Sciences
  Cardiff University
Telephone  029 2251 0665
Email  dewitt@cardiff.ac.uk
Homepage  https://www.cardiff.ac.uk/people/view/39492-dewitt-sharon

My Interests

 Cartilage, Osteoarthritis, Matrix, Inflammation, Neutrophil, Biomarker

Osteoarthritis remains a major challenge, with no disease modifying drugs available. Development of an artificial synovial joint would facilitate identification of early disease markers and also facilitate rapid drug screening. We have developed a 3D cartilage model from human chondrocyte progenitor cells, which has similar biochemical, histological and mechanical properties to native human articular cartilage. We hope to integrate our cartilage model with other joint-relevant material (bone, synovium, etc) to create an in vitro system that can replicate joint tissue responses.

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